Quer-C Powder : This product contains a powerful blend of antioxidants Vitamin C and Quercetin to reduce inflammation and regulate histamine levels. The combination of quercetin and vitamin C works as a natural anti-histamine to manage allergies, gut inflammation, skin inflammation and brain inflammation. Advanced Dosage: Take grams up to 1 tsp — times daily with meals. Move your mouse over image or click to enlarge. Histamine Support Pack Dr. What is Histamine? Histamine receptors are located all over the body and have many important functions including: Histamine H1 receptors: Smooth muscle and endothelial cells affecting skin; blood vessels Benadryl and Claritin block activity of these receptors Histamine H2 receptors: Cells in the intestines control acid secretion, abdominal pain, and nausea; heart rate Histamine H3 receptors: Central nervous system controlling nerves, sleep, appetite and behavior Histamine H4 receptors: Thymus, small intestine , spleen, colon, bone marrow and white blood cells; inflammatory response One of the major effects of histamine is causing the blood vessels to swell and dilate.
When Does Histamine Become a Problem? Key Histamine Reducing Supplements There are several supplements that help the body to reduce histamine levels naturally. Normal Dosage: 2 caps — 2x daily Advanced Dosage: 3 caps — 2x daily Hista Protect : This is a patented enzyme formula containing diamine oxidase DAO —the main enzyme responsible for the degradation of ingested histamine.
Normal Dosage: Take 1 cap with each meal Advanced Dosage: Take 2 caps with each meal Quer-C Powder : This product contains a powerful blend of antioxidants Vitamin C and Quercetin to reduce inflammation and regulate histamine levels. An individual with histamine intolerance has an exaggerated reaction to high histamine foods or foods that produce histamine.
The causes of this exaggerated reaction could be insufficient DAO enzyme production needed for proper histamine metabolism or elevated histamine levels. With histamine intolerance, a person will notice improvement with a low histamine diet and supportive supplements. A person with MCAS may still be very sensitive even with diet, supplement, and lifestyle strategies. Additionally, MCAS is a potentially more debilitating condition than histamine intolerance affecting multiple organ systems. For more information on histamine intolerance, check out this article.
People with MCAS are more sensitive to toxins and environmental changes. Antigens and toxins overwhelm the mast cells and exceed the ability of mast cells to respond. There are a number of antigens or toxins that can trigger MCAS.
These include mold, chemicals, parasites , bacterial infections, allergens, viruses, heavy metals, and toxins. Stress mental, physical, and emotional , heat or cold, hormonal changes, and excessive exercise may also trigger an overreaction of mast cells.
Mast cell activation is linked to certain cancers, cardiovascular diseases, connective tissue disorders, inflammation, allergies, asthma, irritable bowel syndrome , skin conditions, and autoimmune diseases 5. Mast cells and inflammation of the brain are linked to mental health conditions, including depression and anxiety. An inflammatory response to mold exposure can be a driver of MCAS.
If you have MCAS, it is important to check for mold exposure and remove yourself from any water damaged buildings. Mold toxicity occurs when mycotoxins produced by mold lead to a chronic inflammatory immune response. This can be very damaging to the body. To test for mold toxicity, you can do a Mycotoxin Test. This urine test screens for seven different mycotoxins from four species of mold.
Lyme disease is an infectious disease caused by four main species of Borrelia bacteria. It is transmitted by the bite of an infected tick. Lyme disease, as with other infections, can cause mast cells to react and secrete proinflammatory cytokines 6.
There are a number of symptoms associated with Lyme disease, many of which are also common with MCAS. Lyme disease can be very difficult to accurately diagnose. Lyme disease can be very challenging to overcome.
However, there are effective natural strategies that you can find here. Methylation is one of the most essential metabolic functions in the body. It is dependent upon a variety of enzymes that transfer methyl groups onto proteins, amino acids, DNA, and enzymes in every cell and tissue.
It helps to regulate healing, cellular energy, genetic expression of DNA, liver detoxification, immunity, and neurology. This article explains the role of methylation in human health.
Methylation one of the most important pathways through which the body breaks down histamine. The most common genetic variant affecting methylation is the methylenetetrahydrofolate reductase MTHFR gene. If methylation is not working well, there are not enough methyl groups to bind to a receptor site on histamine.
Histamine is not broken down, and high levels of histamine can accumulate in the body. This causes histamine overload and results in symptoms associated with histamine intolerance and MCAS. Mast cells are found in connective tissues throughout the body. EHS is a group of complex and multisystem connective tissue disorders.
There are 13 subtypes of EHS, each with a specific genetic basis and protein involvement. EHS mostly affects the joints and skin. An unusually large range of joint movement hypermobility occurs in most forms of EHS. Loose joints are unstable and prone to dislocation and chronic pain.
Soft, velvety skin that is highly elastic, fragile, and bruises easily is also common. Bone, gastrointestinal, eye, and heart issues are also common with EHS.
POTS is a condition that affects the autonomic nervous system and alters blood flow throughout the body. A person with POTS has an increased heart rate and dizziness or lightheadedness when standing. When a person also experiences flushing, MCAS should be considered. For more information on POTS and strategies to improve this condition, check out this article. Mast cells are in the central nervous system where they contribute to the normal behavioral development and functioning 9.
They have also been linked to numerous neuroinflammatory conditions of the central nervous system. There is growing research on the relationship between mast cells and cancer Researchers have found a significant increase in the prevalence for melanoma and cancers of the breast, cervix, ovaries, lungs, and thyroid in people with MCAS Mast cells can be directly activated by cancer cells.
Mast cells appear to have a dual role in cancer. They can infiltrate tumors and function to promote or restrict tumor growth and invasiveness. By releasing chemokines and initiating an immune response, mast cells may lead to tumor eradication.
However, mast cells may release other mediators that support tumor malignancy. Regulating mast cell activation, recruitment, and type of released mediators at the tumor site can be useful for managing and controlling tumor growth Sensitivity to electromagnetic fields EMFs can play a role in activating mast cells.
There are a broad range of symptoms associated with EMF sensitivities. These include cognitive issues, insomnia, fatigue, dizziness, joint pain, palpitations, and ringing in the ears. It is important to reduce the amount of exposure to non-native EMF and to increase exposure to natural forms of EMF available by being outside grounded on the Earth and getting quality sun exposure. For more information on the dangers of EMFs along with ways to protect yourself from exposure, see this article.
MCAS is a challenging condition to deal and each individual suffering with this will need their own specific health plan. There are several things that are common and effective for the vast majority of people dealing with MCAS. Some individuals will need to avoid all higher histamine foods while others can tolerate some of them. Experimentation will be key to try to understand what your body tolerates and what it cannot and the supplements that seem to offer the most support. Packed in water should be very good for someone with histamine intolerance.
Great article Dr. What about duck eggs, could they be more tolerable than chickens eggs? Eggs are not high histamine so they are fine, however, for some individuals, they may have a food sensitivity to them.
Duck eggs may be more tolerable. Here is another ingredient, TBHQ, which like carrageenan, has caused me serious health issues. This synthetic ingredient is made up of phenols and butane. Eliminating this and carrageenan have given me my life back. I thought you would like to do a followup on this poison for the benefit of your readers.
I have to wonder how many people with histamine intolerance are just allergic to a certain ingredient or ingredients. This appears to be my situation. Thanks for all you do. Thanks for letting us know about this Mike and I will have my research team look into writing an article about that!
The allergy defense has derivatives from pineapple! There are a few great studies out there showing the histamine inhibiting effects of watercress and pea sprouts. My food list is super restrictive. I personally react to olives in water and sea salt but not olive oil. I have been AIP for a year and my antibodies have been dropping, I also found a correlation between my histamine high when my antibodies went up slightly.
What about seeds and histamine? Chia, sesame, sunflower etc? Thanks for your input. Sorry to hear about your struggles. Bromelein is an enzyme that works well at metabolizing histamines and I have used it Allergy Defense clinically with people with histamine intolerance with very good results.
Seeds can increase histamine so your inability to tolerate them is most likely due to that. Olives in water are higher histamine than olive oil. Hope that helps! Our functional doctor just diagnosed our 9 yo daughter with histamine intolerance. Hi Nicole..
I was wondering the same thing; that you are after reading the issue of probiotics being a risky consideration. Hoping the doctor can leave a response on this thread. By Dr. I tried this link and it is no longer valid. Are you now recommending a different SBO probiotic? You can slowly work up to 2 caps — 2x daily. I will be emailing all my friends and family a link to this article in hopes that they might gain an insight and recognize I am not the hypochondriac they have deduced I was for all these years.
You have truly written the most concise and easily understandable explanation of HIT on the internet… thanks for sharing! Subject: Probiotics.. I could use some expert medical advice on this. For more information: google.. A list of books will pop up, etc. Recently; I noticed they now sell probiotics; on their web site.
I would love to know if their is a safe probiotic for those of us who have histamine issues. I really want to heal my gut issues and bring back the good bacteria. I just started the GAPS diet this week.
This is a great suggestion. I just added a section discussing the right probiotics for histamine intolerance. Please do your homework. Jockers, please address this!
Dr Jockers, I have a 16 year old that I believe may be suffering from histamine intolerance. Your article was very clear and informative. We will test fermented foods to try and pinpoint that this is the problem.
Thank you! Thank you Cindy. When we are overly stressed, it will drive up inflammation and make us much more prone to conditions like histamine intolerance.
We can keep that in remission with healthy lifestyle, keeping stress down, good sleep, advanced supplementation, etc. Doctor, I have been researching gut issues for my son and for my furbaby struggle;ing with mast cell tumors, Im ordering several of your products today for my son but was wondering if your products specifically the Allergy Defense and Prescript Assist Broad Spectrum can be used on dogs? Sorry to hear about your son! The recommended dosages are for a lb individual, so based on that, lower the dosage of allergy defense for your son and start low and gradually work up same with your dog.
The Prescript assist you can begin with 2 caps. Also, will following this diet help me to tolerate even the low Histamine foods at some point?
For example, I cannot eat coconut, fruit other than banana, or leafy greens due to intestinal reactions. Unfortunately dairy is a higher histamine food. If you have a histamine intolerance than reducing histamine load can help your body heal, which should help you reduce other food sensitivities. You recommend some type of diet especially, to avoid allergies of any kind, such as allergy to histamine Vegetarian Vegan Macrobiotic Diet according to blood group.
Hello from Quebec Canada Thank you so very much for your your article, following an anaphylasic shock I went to the ER, all test were negative, I am waiting for an appointment with an allergist. I had all the symptoms and burning skin sensation. I thought I was allergic to the sun.
I wish continued healing for you as you move forward. But where in turn then histamine int. From wrecked immune system? Histamine intolerance could be due to several factors overexposure, autoimmunity, chronic inflammation, etc. If you are having GI issues as well leaky gut could also be a culprit. I just found out about this histamine intolerance. Previously I thought I was allergy to seafood. But when I ate fresh seafood, there was no allergy reaction. Furthermore, I was diagnosed with endometriosis stage Does this has relation with histamine intolerance.
I am a little bit confused with the choice of foods. Not only I have to avoid foods with histamines but also foods that is bad for endometriosis. Hey Mary, they could have a similar underlying cause. It would require some investigation. Hi Dr. Jockers I have seen food lists that say no to peanuts but peanut butter is ok. What is your opinion? I also see no cashews—what about cashew milk and cashew butter? I am so happy I found your website. You have helped me tremendously after some unsuccessful derm visits with misdiagnosis.
One last question if I may— every summer I get awful rashes on arms when working in my gardens. That is what I think finally triggered this awful HIT to hit me and spread from arms to rest of body. I am finally clearing after four months by following your advice. Most of my body has cleared with the exception of my arms. Is it possible my arms are super sensitive or super triggered due to repeated exposure and rash on arms every summer??? Can histamines be stored in there??? Thank you!!!
I think I fall into the medication induced histamine intolerance category. I took Zyrtec brand antihistamine, daily, for approximately 10 years. So began my horrific journey of trying to end my Zyrtec dependency. Each time I attempted to stop taking Zyrtec, withdrawal itching, phantom pinpricks, flushing, etc. I was convinced I was allergic to something and still needed Zyrtec.
It was an endless cycle. After a hiking fall, my doctor discovered my liver was inflamed. I do not use drugs, tested negative for all hepatitis strains, and am not a big drinker. The only meds I was taking was Zyrtec and a multivitamin. My doctor assured me Zyrtec was safe to continue using. I went online and started educating myself. It turns out, hundreds of thousands of consumers have experienced adverse effects of long-term Zyrtec use.
There is a whole online community, although many doctors still argue the Zyrtec withdrawal phenomenon is not real. I stopped Zyrtec cold turkey almost 5 months ago. I went through weeks of horrific withdrawal, and a flood-gate of histamine in my body.
Reading this article was a light-bulb moment for me! I have experienced a firestorm of itching, hives, flushing, etc. My body and tissues feel as if I am retaining fluid. My skin has become super sensitive and reacts to even the slightest pressure, resulting in an episode similar to those suffering from chronic idiopathic urticaria.
I was never diagnosed with this condition, and did not experience this type of allergic reaction, prior to using Zyrtec. My questions are: 1. Is my body now irreparably histamine intolerant? How do I reduce the internal inflammation, water retention, etc.? I am not currently on any medication.
I stopped the multivitamin, as it seemed to make me itch more vitamin C? I started taking Align probiotic, hoping to alleviate my IBS type symptoms. Please help! Hey Cherie, thank you for sharing this information and so sorry to hear what you are going through. There are probably a number of factors that need to be addressed in a periodical manner to fully tackle whatever is going on in your body.
Reach out to michael drjockers. In my experience Zyrtec is absolutely addictive and has withdrawal symptoms. It works on my asthma, but I noticed that if I start taking a half-Zyrtec every other day the asthma goes away. But after a week I need to take a half-Zyrtec every night.
Then the asthma starts getting worse and I need to take a full Zyrtec every night to control it. I have found greater success with inhaled steroids for short periods to reduce my asthma without withdrawal. Usually a week or two of Flovent will wipe out the asthma.
I recently started showing signs of cholinergic urticaria without the welts. So many of my other issues now make sense too now that I realize I likely have histamine intolerance. Thank you so very much for this article. My HIT has dramatically worsened after several possible triggers that occurred around the same time in my life. Moved from city to hills area, had first child, stressful pregnancy and very challenging first couple of years.
Other symptoms include foggy brain, low energy and mood, poor internal stress management, eye complaints. I have pyroluria and have been on standard supplement regime for this for 12 months.
Also following gut health and low histamine diet for last month. Diet prior was good and had no sensitivities, therefore i suspect food will not be an issue for me once i get Histamine build up under control. So, my question is — is there any way to determine what type of histamine source i should work on restricting most?
And, is there a treatment approach that is best at targeting the skin? I hope this makes sense, i am still getting my head around understanding how histamine works in our bodies so i can try figure out what it is doing in my body. I have not been able to identify any consistent triggers for my HIT issues, despite great effort. Hey Holli, this would likely come down to reducing histamine sources while improving histamine metabolism in the body while identifying different stressors in your environment whether it be food, mold, underlying sensitivities.
We do have a protocol for improving degradation and addressing all of these factors together may make a big difference in improving inflammation and helping to resolve your skin issues. You can email michael drjockers. Can you ever recover from this? Is coconut yogurt ok? Yes you can definitely recover. I would recommend avoiding coffee and coconut yogurt during your histamine avoidance phase. Still plenty of good foods to enjoy though! These lists are so confusing. It says nuts are high-histamine foods and should be avoided.
However, almond butter is in the low-histamine list. You just have to listen to your own body and lower your overall histamine load I suppose. Thanks for the information.
I would avoid almonds and almond butter to reduce your overall histamine load but yes, symptoms can vary and some do better on certain foods than others.
I was wondering if almond flour was ok on a low histamine diet. If not, what kind of flour would you recommend? Thank you so much for the informative article! It pretty much sums up my issues that came out of the blue following a cortisone injection I received for a running injury.
Fermented foods are out, but what foods are recommended? I have exactly the same symptoms. Google it. There is lots of information on it. I have opted for Mitochondrial Replacement Therapy devised by NASA scientists that a relatively 2 hours away local nutritionist offers.
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